4-Quinolinecarboxamide, 1,2-dihydro-2-oxo-N-[2-(phenylmethyl)phenyl]-
ER-000444793
CAS: 792957-74-5
Molecular Formula: C23H18N2O2
4-Quinolinecarboxamide, 1,2-dihydro-2-oxo-N-[2-(phenylmethyl)phenyl]- - Names and Identifiers
4-Quinolinecarboxamide, 1,2-dihydro-2-oxo-N-[2-(phenylmethyl)phenyl]- - Physico-chemical Properties
| Molecular Formula | C23H18N2O2 |
| Molar Mass | 354.4 |
| Solubility | DMSO: ≥ 100 mg/mL |
| Storage Condition | -20℃ |
| In vitro study | ER-000444793 is a small molecule, non-toxic mPTP inhibitor with a mechanism of action independent of CypD inhibition. ER-000444793 potently and dose-dependently inhibits Ca 2+ -induced mPT. ER-000444793 binds CypD, a CsA/CypD homogenous time-resolved fluorescence (HTRF) assay is used to study compound binding. Both CsA and SfA dose-dependently decrease HTRF signal, suggesting displacement of labelled CsA from rhCypD protein (CsA IC 50 =23 nM and SfA IC 50 = 5 nM). In contrast, ER-000444793 has no effect up to a concentration of 50 μM, indicating lack of displacement of labelled-CsA from rhCypD protein. Together, these data suggest the mechanism of ER-000444793 in delaying mPT is independent of CypD functional inhibition. |
4-Quinolinecarboxamide, 1,2-dihydro-2-oxo-N-[2-(phenylmethyl)phenyl]- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.822 ml | 14.108 ml | 28.217 ml |
| 5 mM | 0.564 ml | 2.822 ml | 5.643 ml |
| 10 mM | 0.282 ml | 1.411 ml | 2.822 ml |
| 5 mM | 0.056 ml | 0.282 ml | 0.564 ml |
Last Update：2024-01-02 23:10:35
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Product Name: ER-000444793 Visit Supplier Webpage Request for quotationCAS: 792957-74-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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